![]() Although the individual pathways for PG and OM synthesis and assembly are well characterized, almost nothing is known about how the biogenesis of these essential surface layers is coordinated. Understanding the molecular mechanisms underlying the assembly of the Gram-negative envelope therefore promises to aid the development of new treatments effective against the growing problem of drug-resistant infections. The biogenesis pathways that build the surface are also targets of many of our most effective antibacterial therapies3. This complex envelope presents a formidable barrier to drug entry and is a major determinant of the intrinsic antibiotic resistance of these organisms2. Coordination of bacterial cell wall and outer membrane biosynthesisĬoordination of bacterial cell wall and outer membrane biosynthesis,Gram-negative bacteria surround their cytoplasmic membrane with a peptidoglycan (PG) cell wall and an outer membrane (OM) with an outer leaflet composed of lipopolysaccharide (LPS)1.Have lot of admiration, respect for Gautam Adani, his company: Abbott,Read more about Have lot of admiration, respect for Gautam Adani, his company: Abbott on Devdiscourse Tags: Abbot Abbott adani Adani Group Adani Groups Australia Australian carmichael China Devdiscourse Energy & Extractives Gautam Adani Hindenburg research INDIA Indians Queensland Tony Abbott ![]()
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